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Friday, November 29, 2013


Photodynamic therapy for                                        intractable bronchial lung cancer.

Photodiagnosis Photodyn Ther. 2013 Dec;10(4):672-6.  Sep 10.

Source

Oncology Department of Nanfang Hospital, Southern Medical University, Guangzhou 51015, China.

Abstract

OBJECTIVE:

To investigate the effectiveness and side effects of photofrin-photodynamic therapy (PDT) for intractable bronchial lung cancer.

METHODS:

Thirty patients were classified as stage II-IV intractable bronchial lung cancer with lumen obstruction after they failed previous treatment regimens such as surgery, radiotherapy and chemotherapy. PDT was performed with 630nm laser light (Diomed) delivered through cylinder diffusing tip quartz fibers that was passed through the biopsy channel of a flexible endoscope 48h after intravenous injection of the photosensitizer photofrin (2mg/kg body weight). 72h after the first irradiation, the endoscopic procedure was repeated, necrotic tissues were mechanically removed and the deep original lesions and newly exposed cancer lesions were re-treated, and, if necessary, the areas were cleaned repeatedly.

RESULTS:

The total response rate CR+PR was 86.7%, and the mean percentage of obstruction due to tumors at different treated sites decreased from 90% to 16.7% at discharge after PDT. The KPS score was significantly improved after PDT.

CONCLUSIONS:

PDT of intractable bronchial lung cancer effectively reduces the amount of lumen obstruction, and improves the patient's quality of life. It may be an effective palliative treatment with minor side effects on patients with advanced bronchial lung cancer.
Copyright © 2013 Elsevier B.V. All rights reserved.

KEYWORDS:

Intractable bronchial lung cancer, Obstruction, Photodynamic therapy, Photofrin

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